First Method:


  1. Sign into the Office 365 Portal. 
  2. Locate Users > Active Users or Groups > Shared Mailboxes if this is a shared mailbox.
  3. Select a user who has a Microsoft Exchange mailbox. 
  4. On the menu on the right, locate Mail settings > Automatic Replies


Second Method: 


  1. Sign into the Office 365 Admin portal using your admin credentials. 
  2. Expand the Admin Centers panel, then select Exchange.
  3. Click the picture in the top right-hand corner. Select Another User, and then select the user mailbox that you wish to change.
  4. On the left side, select Options, click on Organize e-mail, and then click on Automatic Replies.




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